Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System

Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System
February 2005
Keun Sang Oh, Kyung Eun Lee, Sung Sik Han, Sun Hang Cho, Dongmin Kim, and Soon Hong Yuk
Biomacromolecules. 2005 Mar-Apr;6(2):1062-7.
ACS Publications
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Abstract:
A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.