Fluoroalkoxy, nucleosides, nucleotides, and polynucleotides

/Home/Lyophilization and Protein Formulation Patents/Patents - Biologics

Fluoroalkoxy, nucleosides, nucleotides, and polynucleotides
Inventor: VAGLE KURT (US); VARGEESE CHANDRA (US)
Applicant: SIRNA THERAPEUTICS INC (US)
IPC: A61K48/00; C07H21/02; C12Q1/68
Publication info: US2005266422
Date: 2005-12-01
Abstract of US2005266422
The present invention related to fluoroalkoxy ("-OCF3") nucleosides, nucleotides, and polynucleotides comprising fluoroalkoxy nucleotides. The present invention also relates to methods of synthesizing fluoroalkoxy nucleosides, nucleotides, and polynucleotides comprising fluoroalkoxy nucleotides. The present invention also relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity. The invention also relates to fluoroalkoxy modified nucleic acid molecules, such as ribozymes, antisense, aptamers, decoys, triplex forming oligonucleotides (TFO), immune stimulatory oligonucleotides (ISO), immune modulatory oligonucleotides (IMO), and small nucleic acid molecules, including short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against polynucloetide targets. Such small nucleic acid molecules are useful, for example, in providing compositions to treat, prevent, inhibit, or reduce diseases, traits, or conditions in a subject or organism.