ERAAP modulators regulate immune responses

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ERAAP modulators regulate immune responses
United States Patent 7,005,269
Shastri , et al. February 28, 2006
ERAAP modulators regulate immune responses
Inventors: Shastri; Nilabh (Richmond, CA); Serwold; Thomas (El Cerrito, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Appl. No.: 164012
Filed: June 6, 2002
Abstract
An immune response is modulated by selectively inhibiting ERAAP (an acronym for ER aminopeptidase associated with antigen processing) and confirming a resultant immune response modulation. More particularly, the method comprises contacting a patient determined to be in need of immune response modulation with a physiologically acceptable dosage composition comprising an effective amount of an inhibitor of ERAAP activity; confirming a resultant inhibition of said ERAAP activity and confirming a resultant immune response modulation in the patient. A variety of selective inhibitors are shown to be effective, including amino thiols, such as leucine thiol, ERAAP-specific antibody complementarity-determining region, and an ERAAP-specific siRNA.