EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice

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EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice
JANUARY 2006
Alexei Shir1, Manfred Ogris2, Ernst Wagner2, Alexander Levitzki1*
1 Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel, 2 Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universit?t, Munich, Germany
PLoS.org
Background
Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12?14 mo from the time of diagnosis. We describe a novel strategy to selectively induce the death of glioblastoma cells and other cancer cells that over-express the EGF receptor. Using a non-viral delivery vector that homes to the EGF receptor, we target synthetic anti-proliferative dsRNA (polyinosine-cytosine [poly IC]), a strong activator of apoptosis, selectively to cancer cells.
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