Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system.

Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system.
May 19, 2004
JM Llabot, RH Manzo, and DA Allemandi
Int J Pharm
Medline Abstract
HighWire Press
Departamento de Farmacia, Facultad de Ciencias Qu?micas, Universidad Nacional de C?rdoba, Ciudad Universitaria, 5000 C?rdoba, Argentina.
In vitro mucoadhesion, water uptake, and drug release of nystatin (N) from matrices of carbomer (C) and lyophilized carbomer sodium salt (CNaL) mixtures were evaluated. Matrices with different ratios C:CNaL were prepared by direct compression. Commercial C as well as lyophilized powder (CL) were used. In vitro mucoadhesion increased as the proportion of C in the matrix was raised. The same effect was observed when C was replaced by CL. Matrices in which C was replaced by CL showed an increase of both water uptake and release rates. Besides, the release of N from matrices CL:CNaL exhibited a kinetics with Super Case II (n>1) mechanism. However, for C:CNaL matrices, drug release was slower and exhibited a biphasic profile with a first stage characterized by either an anomalous (n<1, for C>or=50%) or a Case II (n approximately 1.0, C<50%) mechanisms. After that period, the mechanism changed to Super Case II transport (n>1).
Publication Type:
Journal article
MeSH Terms:
Acrylic Resins
Antifungal Agents
Drug Delivery Systems*
Nystatin
Research Support, Non-U.S. Gov't
Tablets
Water
PMID: 15113614
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