Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle

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Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle
Inventor: MIZUSHIMA YUTAKA (JP); OGAWA YASUAKI (JP)
EC: A61K9/16H2; A61K31/00
IPC: A61K33/42; A61K33/42
Publication info: US2006153930
2006-07-13
Abstract of US2006153930
Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.