Determination of the stabilities of new quinazoline derivatives by HPLC
Determination of the stabilities of new quinazoline derivatives by HPLC
Engineering Village 2
2006 Elsevier Inc.
Accession number: 063310072332
Title: Determination of the stabilities of new quinazoline derivatives by HPLC
Authors: Baszczak-Switkiewicz, K.; Mikiciuk-Olasik, E.
Author affiliation: Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lodz 90-151, Poland
Serial title: Journal of Liquid Chromatography and Related Technologies
Abbreviated serial title: J. Liq. Chromatogr. Relat. Technol.
Volume: v 29
Issue: n 16
Issue date: Sep 1 2006
Publication year: 2006
Pages: p 2367-2385
Language: English
ISSN: 1082-6076
CODEN: JLCTFC
Document type: Journal article (JA)
Publisher: Taylor and Francis Inc., Philadelphia PA, PA 19106, United States
Abstract: The quinazoline derivatives reported in this work belong to a new group of compounds with a type of chemical bonding that has potential anticancer features. A biochemical study determining anticancer activity of quinazoline derivatives and N3 -quinazoline oxide will be conducted in the medium of 0.2% DMSO. The HPLC method was used to determine stabilities of these compounds in a biochemical study environment. Optimisation of the chromatographic system and validation of the established analytical method was performed. Analysis of the stabilities of the derivatives examined was performed in the reversed phase RP-18 system, in which pure acetonitrile was used as an eluent for the analysis of compounds 1 and 3 , and a mixture of acetonitrile/methanol in the ratio of 95/5% for compounds 2 and 4 . The HPLC analysis revealed that the compounds studied are homogeneous in the 0.2% DMSO medium, up to 96 hours. Copyright ? Taylor and Francis Group, LLC.
Number of references: 8
Ei main heading: Nitrogen compounds
Ei controlled terms: Derivatives - Stability - Chemical bonds - Tumors - Biochemistry - High performance liquid chromatography - Acetonitrile - Methanol
Uncontrolled terms: HPLC - RP-18 - Quinazoline - Quinazoline N3oxide
Ei classification codes: 804.1 Organic Compounds - 801.4 Physical Chemistry - 801.2 Biochemistry
Treatment: Theoretical (THR)
DOI: 10.1080/10826070600864817
Database: Compendex
Compilation and indexing terms, ? 2006 Elsevier Inc. All rights reserved
Subscription required: http://www.engineeringvillage2.org
Votes:14
Comments: 0