DRY POWDER INHALATION SYSTEM FOR TRANSPULMONARY ADMINISTRATION
Patent number: MXPA03011541
Publication date: 2004-03-19
Inventor: CHIKAMASA YAMASHITA (JP)
Applicant: OTSUKA PHARMACEUTICALS CO LTD (JP)
Classification:
- international: A61K9/12; A61K9/72; A61M15/00
- european:
Application number: MX2003PA11541 20031211
Priority number(s): WO2002JP05955 20020614; JP20010182504 20010615; JP20010400871 20011228
Abstract of MXPA03011541
It is intended to provide a novel dry powder inhalation system for transpulmonary administration. This dry powder inhalation system for transpulmonary administration contains a single dose of the active ingredient and is characterized by comprising a combination of a container packed with a freeze-dried composition having the following properties: (i) being in the form of a non-powder cake; (ii) having a decay index of 0.015 or above; and (iii) upon an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec, being disintegrated into fine particles having an average particle diameter of 10 mum or below or an effective particle ratio of 10% or above; with a device provided with means of imparting the above air impact to the freeze-dried composition in the above container and means of discharging the powdery freeze-dried composition having been disintegrated into fine particles from the container.
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