Cyclodextrin nanoaggregates and their assembly with protein: a spectroscopic investigation
Cyclodextrin nanoaggregates and their assembly with protein: a spectroscopic investigation
Engineering Village 2
2006 Elsevier Inc.
Accession number: 8965227
Title: Cyclodextrin nanoaggregates and their assembly with protein: a spectroscopic investigation
Authors: Micali, N.1 ; Villari, V.1 ; Mazzaglia, A.; Scolaro, L.M.; Valerio, A.; Rencurosi, A.; Lay, L.
Author affiliation: 1 CNR-Inst. per i Processi Chimico-Fisici, Messina, Italy
Serial title: Nanotechnology
Abbreviated serial title: Nanotechnology (UK)
Volume: 17
Issue: 13
Publication date: 14 July 2006
Pages: 3239-44
Language: English
ISSN: 0957-4484
CODEN: NNOTER
Document type: Journal article (JA)
Publisher: IOP Publishing
Country of publication: UK
Material Identity Number: N798-2006-010
Abstract: Light scattering and time-resolved fluorescence spectroscopy results showed that specially designed amphiphilic cyclodextrins are able to bind a specific protein, PA-I lectin. When containing a galactosyl group, the self-assembled cyclodextrins interact with the protein affecting the dynamical properties of the system and the fluorescence lifetimes (as well as the fluorescence anisotropy) of the protein itself. The self-assembled cyclodextrins containing a glucosyl group, on the other hand, do not induce any change in these measured quantities, suggesting no interaction with protein. This binding capability of galactosyl-modified cyclodextrins offers perspectives on exploiting self-assembled supramolecular structures as nano-carriers to deliver drugs to target tissues
Number of references: 41
Inspec controlled terms: drug delivery systems - fluorescence - light scattering - molecular biophysics - nanotechnology - proteins - self-assembly - time resolved spectroscopy
Uncontrolled terms: cyclodextrin nanoaggregates - protein - spectroscopic investigation - time-resolved fluorescence spectroscopy - light scattering - amphiphilic cyclodextrins - galactosyl group - self-assembled cyclodextrins - dynamical properties - fluorescence lifetimes - fluorescence anisotropy - glucosyl group - binding capability - galactosyl-modified cyclodextrins - self-assembled supramolecular structures - nano-carriers - drug delivery - tissue targeting
Inspec classification codes: A8783 Nanotechnology applications in biomedicine - A8715M Interactions with radiations at the biomolecular level - A8770G Patient care and treatment
Treatment: Experimental (EXP)
Discipline: Physics (A)
DOI: 10.1088/0957-4484/17/13/027
Database: Inspec
Copyright 2006, The Institution of Engineering and Technology
Subscription required: http://www.engineeringvillage2.org
Votes:29
Comments: 0