Compositions and methods for treatment of prostate and other cancer

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Compositions and methods for treatment of prostate and other cancers
United States Patent 7,101,991
Gleave , et al.
September 5, 2006
Inventors: Gleave; Martin E. (Vancouver, CA), Rocchi; Palma (Vancouver, CA), Signaevsky; Maxim (Vancouver, CA), Beraldi; Eliana (Vancouver, CA)
Assignee: The University of British Columbia (Vancouver, CA)
Appl. No.: 10/605,498
Filed: October 2, 2003
Abstract
Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp27 mRNA, for example human hsp27 mRNA, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically acceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is an injectable dosage unit form.