Compositions and methods for nucleic acid delivery to the lung
Title: Compositions and methods for nucleic acid delivery to the lung
United States Patent: 5,994,314
Inventors: Eljamal; Mohammed (San Jose, CA); Patton; John S. (San Carlos, CA); Foster; Linda (Sunnyvale, CA); Platz; Robert M. (Half Moon Bay, CA)
Assignee: Inhale Therapeutic Systems, Inc. (San Carlos, CA)
Appl. No.: 422563
Filed: April 14, 1995
Abstract
A dry powder composition comprises insoluble nucleic acid constructs dispersed within with a hydrophilic excipient material, where the powder particles have an average size in the range from 0.5 .mu.m to 50 .mu.m. Nucleic acid constructs may comprise bare nucleic acid molecules, viral vectors, or vesicle structures. The hydrophilic excipient material will be selected to stabilize the nucleic acid molecules in the constructs, enhance dispersion of the nucleic acid in dry powder aerosols, and enhance wetting of the nucleic acid constructs as they are delivered to moist target locations within the body.
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