Comparative Evaluation of Lyophilized Freeze Dried Platelet Derived Preparation with Calcium Hydroxide as Pulpotomy Agents in Primary Molars.

Comparative Evaluation of Lyophilized Freeze Dried Platelet Derived Preparation with Calcium Hydroxide as Pulpotomy Agents in Primary Molars.
KALASKAR R Ra, DAMLE S Gb
Nair Hospital Dental College
ABSTRACT
The aim of this study was to compare the efficacy of lyophilized
freeze dried platelet derived preparation with calcium hydroxide as
pulpotomy agents in primary molars. Fifty six primary molars in 28
children were treated by a conventional pulpotomy technique. 28
teeth were treated by lyophilized freeze-dried platelet derived preparation
and another 28 by calcium hydroxide. Clinical evaluation
was carried out out at 1, 3, and 6-months interval and the radiographic
evaluation was carried out at land 6-months. The success
rate of lyophilized freeze-dried platelet derived preparation proved
better than calcium hydroxide.
Key Words : Calcium hydroxide, Deciduous teeth, Freeze
dried platelet derived preparation, Pulpotomy.
INTRODUCTION
The pulpotomy is a surgical procedure that involves surgical
amputation of coronal infected portion of vital pulp followed
by application of medicament over the residual radicular pulp
tissue to promote healing and also to allow normal tooth
physiology to continue1,2. Formocresol, a devitalizing agent
has been reported to be carcinogenic and mutagenic3,4.
Glutaraldehyde, a preservative agent has been proposed as
an alternative to formocresol, that results in inadequate fixation
and leaves a deficient barrier to sub base irritation, resulting
to internal resorption5,6. Ferric sulfate has received some
attention recently as a pulpotomy agent. Although the metal
protein clot at the surface of the pulp stump acts as a barrier
to the irritating components at the sub base, it functions solely
in a passive manner7,8. Calcium hydroxide, a regenerative
pulpotomy agent, has been reported to be a failure in primary
teeth due to higher incidence of the development of chronic
pulpal inflammation and internal resorption9,10. However, recent
studies have reported a favorable result for calcium hydroxide
by controlling the variables of treatment such as pulpotomy
technique, strict selection criteria, etc 11,12.
Recent advances in the field of bone and dentin formation
have opened new vistas for pulp therapy. Bone Morphogenetic
proteins (BMPs) and Growth factor [such as transforming
growth factor (TGF), platelet derived growth factor (PDGF),
insulin growth factor (IGF)] derived from platelet have generated
considerable interest during the last few years13,14. These
compounds act as signaling proteins that could be directly
involved in the regulation of cell proliferation, migration and
extra cellular matrix production in the dental pulp15,16. Hence,
these could prove to be feasible alternatives to the materials
currently used for pulpotomy. The present study was aimed
to evaluate the clinical and radiographic efficacy of lyophilized
freeze dried platelet derived preparation and calcium hydroxide
as pulpotomy agents in primary molars.
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