Chemical synthesis of RNA including 5-taurinomethyluridine

/Home/Biologics Delivery - Protein Synthesis/RNA - Protein Synthesis

Chemical synthesis of RNA including 5-taurinomethyluridine
2006
Toshihiko Ogata and Takeshi Wada
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The Universitiy of Tokyo, Bioscience Bldg 702, Kashiwa, Chiba 277-8562, Japan
Nucleic Acids Symposium Series 2006
Recently, a novel base-modified uridine derivative, 5-taurinomethyluridine (m5U) was discovered from bovine and human mitochondrial tRNAs, and this modified ribonucleoside was found to existed at the first position of the anti-codon. We report efficient reactions for the synthesis of RNA oligomers including this base-modified ribonucleotide.
Please visit the web site to view the article in its entirety.