Chemical compounds

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United States Patent Application 20050143368
Kind Code A1
Starke, Ingemar ; et al. June 30, 2005
Chemical compounds
Abstract
The present invention relates to compounds of formula (1): wherein R.sup.v, R.sup.1, R.sup.2, R.sup.x, R.sup.y, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.z and v are as defined within; pharmaceutically acceptable salts, solvates, solvates or such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
Inventors: Starke, Ingemar; (Molndal, SE) ; Dahlstrom, Mikael, Ulf, Johan; (Molndal, SE) ; Nordberg, Mats, Peter; (Molndal, SE) ; Alenfalk, Suzanne; (Molndal, SE) ; Wallberg, Andreas, Christer; (Molndal, SE) ; Bostrom, Stig, Jonas; (Molndal, SE)
Correspondence Name and Address: MORGAN LEWIS & BOCKIUS LLP
1111 PENNSYLVANIA AVENUE NW
WASHINGTON
DC
20004
US

Serial No.: 511984
Series Code: 10
Filed: October 21, 2004
PCT Filed: April 23, 2003
PCT NO: PCT/GB03/01742
U.S. Current Class: 514/211.06; 514/423; 514/460; 514/548; 540/545
U.S. Class at Publication: 514/211.06; 540/545; 514/423; 514/460; 514/548
Intern'l Class: A61K 031/554; A61K 031/401; A61K 031/366; C07D 285/36; A61K 031/225