Carbonylamino-derivatives as novel inhibitors of histone deacetylase - Patent Pending

United States Patent Application 20050148613
Kind Code A1
Van Emelen, Kristof ; et al. July 7, 2005
Carbonylamino-derivatives as novel inhibitors of histone deacetylase
Abstract
This invention comprises the novel compounds of formula (I) wherein n, m, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L, Q, X, Y and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. 1
Inventors: Van Emelen, Kristof; (Sint-Niklaas, BE) ; Verdonck, Marc Gustaaf Celine; (Gierle, BE) ; Van Brandt, Sven Franciscus Anna; (Nijlen, BE) ; Backx, Leo Jacobus Jozef; (Arendonk, BE)
Correspondence Name and Address: Philip S Johnson
Johnson & Johnson
One Johnson & Johnson Plaza
New Brunswick
NJ
08933-7003
US

Serial No.: 507788
Series Code: 10
Filed: September 13, 2004
PCT Filed: March 11, 2003
PCT NO: PCT/EP03/02512
U.S. Current Class: 514/275; 514/235.2; 514/253.01; 544/128; 544/330; 544/360
U.S. Class at Publication: 514/275; 544/330; 514/235.2; 514/253.01; 544/128; 544/360
Intern'l Class: A61K 031/506; C07D 043/02