Blood?brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses - Biologics Delivery

Blood?brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses
Received 23 February 2007; accepted 2 April 2007. Available online 6 April 2007
William M. Pardridge, a
Journal of Controlled Release
Article in Press
ScienceDirect
Copyright ? 2007 Elsevier B.V. All rights reserved.
aDepartment of Medicine, UCLA, Warren Hall 13-164, 900 Veteran Ave., Los Angeles, CA 90024, USA
Abstract
The products of biotechnology, recombinant proteins, monoclonal antibodies, antisense, RNA interference, or non-viral gene transfer, cannot be developed as pharmaceuticals for the brain, unless these molecules are re-formulated to enable transport across the blood?brain barrier (BBB). Large molecule drugs, and plasmid DNA, can be delivered across the BBB with receptor-specific molecular Trojan horses. Trojan horse BBB delivery systems, coupled with one of 3 different technology platforms (fusion proteins, avidin?biotin, or Trojan horse liposomes), can enable the BBB transport of virtually any large molecule drug or plasmid DNA.
Keywords: Blood?brain barrier; Drug targeting; Insulin receptor; Fusion protein
Tel.: +1 310 825 8858; fax: +1 310 206 5163.
Note to users: The section "Articles in Press" contains peer reviewed accepted articles to be published in this journal. When the final article is assigned to an issue of the journal, the "Article in Press" version will be removed from this section and will appear in the associated published journal issue. The date it was first made available online will be carried over. Please be aware that although "Articles in Press" do not have all bibliographic details available yet, they can already be cited using the year of online publication and the DOI as follows: Author(s), Article Title, Journal (Year), DOI. Please consult the journal's reference style for the exact appearance of these elements, abbreviation of journal names and the use of punctuation.
There are three types of "Articles in Press":
Accepted manuscripts: these are articles that have been peer reviewed and accepted for publication by the Editorial Board. The articles have not yet been copy edited and/or formatted in the journal house style.
Uncorrected proofs: these are copy edited and formatted articles that are not yet finalized and that will be corrected by the authors. Therefore the text could change before final publication.
Corrected proofs: these are articles containing the authors' corrections and may, or may not yet have specific issue and page numbers assigned.

You can view the abstract online. A subscription is required to view the full text or it can be purchased online.