Antibodies to mitogenic oxygenases

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Antibodies to mitogenic oxygenases
United States Patent 7,048,923
Lambeth , et al.
May 23, 2006
Inventors: Lambeth; J. David (Decatur, GA); Griendling; Kathy K. (Stone Mountain, GA); Lassegue; Bernard P. (Decatur, GA); Arnold; Rebecca S. (Tucker, GA); Cheng; Guangjie (Atlanta, GA)
Assignee: Emory University (Atlanta, GA)
Appl. No.: 319236
Filed: December 13, 2002
Abstract
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.