AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies - Monoclonal Antibodies

AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies
6 April 2006
Sylvia M Major1 ,4 , Satoshi Nishizuka1 ,5 ,6 , Daisaku Morita1 ,7 , Rick Rowland2 , Margot Sunshine3 , Uma Shankavaram1 , Frank Washburn1 ,8 , Daniel Asin1 ,9 , Hosein Kouros-Mehr1 ,10 , David Kane3 and John N Weinstein
BioMed Central Ltd
Monoclonal antibodies are used extensively throughout the biomedical sciences for detection of antigens, either in vitro or in vivo. We, for example, have used them for quantitation of proteins on "reverse-phase" protein lysate arrays. For those studies, we quality-controlled > 600 available monoclonal antibodies and also needed to develop precise information on the genes that encode their antigens. Translation among the various protein and gene identifier types proved non-trivial because of one-to-many and many-to-one relationships. To organize the antibody, protein, and gene information, we initially developed a relational database in Filemaker for our own use. When it became apparent that the information would be useful to many other researchers faced with the need to choose or characterize antibodies, we developed it further as AbMiner, a fully relational web-based database under MySQL, programmed in Java.
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