2005 Current Trends in Microcalorimetry - July 27-30, 2005 - Boston, MA

2005 Current Trends in Microcalorimetry
July 27-30, 2005 - Boston, MA
Best Western Boston - Inn at Longwood
The conference will focus on rapidly growing application areas for ultrasensitive calorimetry in the life sciences. Hear first-hand experiences from scientists using ITC, DSC and other related technologies in the areas of:

Keynote Presentations by:
Adrian Parsegian, PhD., National Institutes of Health
Alan Cooper, PhD., University of Glasgow, UK
Topics:
Drug Discovery and Pharmaceutics
Protein Stability and Binding
Nucleic Acid Stability and Binding
Macromolecular Stability and Binding
Tutorials
Poster Presentations
TUTORIALS
1:00 pm
ITC: Principles and Experimental Design
Jim Thomson, PhD., Pfizer
1:45 pm ITC: Design of Experiments and Analysis of Data
Joel Tellinghuisen, PhD., Vanderbilt University
2:30 pm BREAK
3:00 pm DSC: Principles and Experimental Design
Chris Johnson, PhD., Cambridge University
3:45 pm DSC: Data Analysis
Michael Blaber, PhD., Florida State University
4:30 pm BREAK

KEYNOTE I 5:00 PM Thermodynamics and Molecular Interactions
Adrian Parsegian, PhD., National Institutes of Health
END OF DAY 1

Thursday, July 28, Morning Session NUCLEIC ACID STABILITY AND BINDING I
8:30 am Microcalorimetry and Biosensor Results for Rational Drug Design: From Monomer Binding to Cooperativity in DNA Minor Groove Interactions
W. David Wilson, PhD., Georgia State University
9:15 am Ligand binding and stability of c-myc silencer elements
Edwin Lewis, PhD., Northern Arizona University
10:00 am BREAK
10:30 am G-quadruplex DNA: ligand binding and stability
Ihtshamul Haq, PhD., University of Sheffield
11:15 am Calorimetric tools for the study of drug-nucleic acid interactions
Jonathan B. Chaires, PhD., University of Louisville Health Science Center
PROTEIN STABILITY AND BINDING I
1:30 pm Engineering Proteins for themostability using rational design
George Makhatadze, PhD., Penn State University - Hershey
2:15 pm Evolutionary optimization of residue environments in proteins
Jose Sanchez-Ruiz, PhD., University of Granada
3:00 pm The increased binding affinities of protease inhibitors for the atazanavir-resistant I50L/A71V HIV-1 protease revealed in three biophysical methods
Mark Witmer, PhD., Bristol Myers-Squibb
3:45 pm Topic to be announced
John Ladbury, PhD., University College London
4:30 pm Thermodynamic Basis for the Development of HIV-1 Entry Inhibitors
Arne Schon, PhD., Johns Hopkins University
Drug Discovery and Pharmaceutics
8:30 am The use of microcalorimetry to study relaxation kinetics in pharmaceutical glasses
Michael Pikal, PhD., University of Connecticut
9:15 am Topic to be announced
LaToya Jones, PhD., University of Colorado Health Science Center
10:00 am BREAK
10:30 am Scan-Rate Dependent Melthing Transitions of Interleukin-1 Receptor (Type II): Elucidation of Meaningful Thermodynamic and Kinetic Parameters of Aggregation Acquired from DSC Simulations
Richard Remmele, PHD., Amgen
11:15 am Topic to be announced
Matthew Todd, PhD., Johnson & Johnson
12:00 pm Topic to be announced
Rachel Kroe, Boehringer-Ingelheim
NUCLEIC ACID STABILITY AND BINDING II
2:00 pm Topic to be announced
Andrew Feig, PhD., Indiana University
2:45 pm Topic to be announced
Daniel Pilch, PhD., UMDNJ, Rutgers University
3:30 pm BREAK
4:00 pm Topic to be announced
David Graves, PhD., University of Alabama - Birmingham
KEYNOTE II 4:45 pm Consider the melting of a snowflake...Another look at heat capacity effects in biomolecular thermodynamics
Alan Cooper, PhD., University of Glasgow
GALA BANQUET
END OF DAY 3

Saturday, July 30 Macromolecular Stability and Binding
8:30 am Pressure perturbation calorimetry and protein secondary structure
Gary Pielak, PhD., University of North Carolina
9:15 am Topic to be announced
Dorothy Becket, PhD., University of Maryland - College Park
10:00 am BREAK
10:30 am Topic to be announced
Hans-Jurgen Hinz, PhD., Universitat Muenster
11:15 am Topic to be announced
Timothy Lohman, PhD., Washington University - St. Louis
12:00 pm Closing remarks