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Lyophilization and Protein Formulation
Toxicity Limits - Protein Formulation

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Metal content of ephedra-containing dietary supplements and select botanicals

Votes:16 Comments:0
Metal content of ephedra-containing dietary supplements and select botanicals Apr 2006 Anne A. Grippo, Bradley Hamilton, Robyn Hannigan and Bill J. Gurley American Journal of Health-System Pharm READ MORE
http://www.ajhp.org/cgi/content/abstract/63/7/635...

Water-soluble amphotericin B?polyvinylpyrrolidone complexes with maintained anti...

Votes:11 Comments:0
Water-soluble amphotericin B?polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects 16 November 2 READ MORE
http://jac.oxfordjournals.org/cgi/content/abstract/57/2/236...

Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxam...

Votes:19 Comments:0
Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer June 10, 2005 William Kevin Kelly, Owen A. O'Connor, Lee M. Krug, Judy H. READ MORE
http://www.jco.org/cgi/content/abstract/23/17/3923...

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethyl...

Votes:14 Comments:0
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil?Based Paclitaxel in Women With Breast Cancer Nov 2005 William J. Gradishar, Sergei Tjulandin, Nevill READ MORE
http://www.jco.org/cgi/content/abstract/23/31/7794...

Safety and Adverse Events Profiles of Intravenous Gammaglobulin Products Used fo...

Votes:8 Comments:0
Safety and Adverse Events Profiles of Intravenous Gammaglobulin Products Used for Immunomodulation: A Single-Center Experience Apr 2006 Ashley A. Vo, Vinh Cam, Mieko Toyoda, Dechu P. Puliyanda, Ma READ MORE
http://cjasn.asnjournals.org/cgi/content/abstract/CJN.01701105v1...

Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medic...

Votes:3 Comments:0
Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties Jan 2006 C. F. Carson, K. A. Hammer, and T. V. Riley Clinical Microbiology Reviews Abstract Compl READ MORE
http://cmr.asm.org/cgi/content/abstract/19/1/50

Phase I and Pharmacokinetics Trial of ABI-007, a Novel Nanoparticle Formulation ...

Votes:36 Comments:0
Phase I and Pharmacokinetics Trial of ABI-007, a Novel Nanoparticle Formulation of Paclitaxel in Patients With Advanced Nonhematologic Malignancies Nov 2005 David W. Nyman, Kimberley J. Campbell, READ MORE
http://www.jco.org/cgi/content/abstract/23/31/7785...

Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given ...

Votes:30 Comments:0
Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given on Days 1 and 8 of a 3-Week Cycle in Patients with Advanced Solid Tumors May 2005 Maja J.A. de Jonge, Ate van der Ga READ MORE
http://clincancerres.aacrjournals.org/cgi/content/full/11/10/3806...

Phase II Study of Denileukin Diftitox for Relapsed/Refractory B-Cell Non-Hodgkin...

Votes:6 Comments:0
Phase II Study of Denileukin Diftitox for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma Oct 2004 Nam H. Dang, Fredrick B. Hagemeister, Barbara Pro, Peter McLaughlin, Jorge E. Romaguera, Dan Jo READ MORE
http://www.jco.org/cgi/content/full/22/20/4095...

Dawn of non-nucleoside inhibitor-based anti-HIV microbicides

Votes:20 Comments:0
Dawn of non-nucleoside inhibitor-based anti-HIV microbicides March 2006 Osmond J. D'Cruz and Fatih M. Uckun Journal of Antimicrobial Chemotherapy Abstract The emergence of HIV/AIDS as a disease READ MORE
http://jac.oxfordjournals.org/cgi/content/abstract/57/3/411...

Bosentan therapy for pulmonary arterial hypertension

Votes:33 Comments:0
Bosentan therapy for pulmonary arterial hypertension Jun 2004 H Cohen, C Chahine, A Hui, and R Mukherji American Journal of Health-System Pharmacy PURPOSE: The etiology, epidemiology, pathophysi READ MORE
http://www.ajhp.org/cgi/content/abstract/61/11/1107...

Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanop...

Votes:28 Comments:0
Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol) Jun 2005 Alex Sparreboom, READ MORE
http://clincancerres.aacrjournals.org/cgi/content/abstract/11/11/4136....

Propylene Glycol-Induced Lactic Acidosis in a Patient with Normal Renal Function...

Votes:3 Comments:0
Propylene Glycol-Induced Lactic Acidosis in a Patient with Normal Renal Function: A Proposed Mechanism and Monitoring Recommendations September 13, 2005 Bruce W Neale, PharmD, Eleanor L Mesler, P READ MORE
http://www.theannals.com/cgi/content/abstract/39/10/1732...

Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pan...

Votes:36 Comments:0
Oseltamivir (Tamiflu?) and its potential for use in the event of an influenza pandemic Feb 2005 Penelope Ward, Ian Small, James Smith, Pia Suter, and Regina Dutkowski Journal of Antimicrobial Che READ MORE
http://jac.oxfordjournals.org/cgi/reprint/55/suppl_1/i5...

Leaching of diethylhexyl phthalate from multilayer tubing into etoposide infusio...

Votes:38 Comments:0
Leaching of diethylhexyl phthalate from multilayer tubing into etoposide infusion solutions Jan 2005 Sandrine Bagel-Boithias, Val?rie Sautou-Miranda, Daniel Bourdeaux, Violaine Tramier, Anne Boyer READ MORE
http://www.ajhp.org/cgi/content/full/62/2/182...

Overview of Oral Modified-Release Opioid Products for the Management of Chronic ...

Votes:11 Comments:0
Overview of Oral Modified-Release Opioid Products for the Management of Chronic Pain Jul 2006 Celene M Amabile and Bill J Bowman The Annals of Pharmacotherapy Abstract OBJECTIVE: To evaluate ph READ MORE
http://www.theannals.com/cgi/reprint/aph.1G259v1...

Fosamprenavir: Drug Development for Adherence

Votes:6 Comments:0
Fosamprenavir: Drug Development for Adherence (CE) (July/August) Jun 2006 E Kelly Hester, Haley V Chandler, and Kelli M Sims The Annals of Pharmacotherapy Abstract OBJECTIVE: To review the phar READ MORE
http://www.theannals.com/cgi/reprint/aph.1G034v1...

Rhabdomyolysis Caused by Commiphora mukul, a Natural Lipid-Lowering Agent

Votes:19 Comments:0
Rhabdomyolysis Caused by Commiphora mukul, a Natural Lipid-Lowering Agent Jul 2004 Antonio Bianchi, Paola Cant?, Fabio Firenzuoli, Gabriela Mazzanti, Francesca Menniti-Ippolito, and Roberto Rasche READ MORE
http://www.theannals.com/cgi/content/full/38/7/1222...

Drug Delivery Systems in Cancer Therapy

Votes:33 Comments:0
Drug Delivery Systems in Cancer Therapy Jun 2004 Karl K Kwok The Annals of Pharmacotherapy An example...advantage in terms of toxicity and responses seen with...certain cases, specialty excipien READ MORE
http://www.theannals.com/cgi/content/full/38/6/1095-a...

FLUTAMIDE METABOLISM IN FOUR DIFFERENT SPECIES IN VITRO AND IDENTIFICATION OF FL...

Votes:28 Comments:0
FLUTAMIDE METABOLISM IN FOUR DIFFERENT SPECIES IN VITRO AND IDENTIFICATION OF FLUTAMIDE METABOLITES IN HUMAN PATIENT URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY Jun 200 READ MORE
http://dmd.aspetjournals.org/cgi/content/full/34/6/984...

Phase I Trial with BMS-275183, a Novel Oral Taxane with Promising Antitumor Acti...

Votes:3 Comments:0
Phase I Trial with BMS-275183, a Novel Oral Taxane with Promising Antitumor Activity Mar 2006 Linda E. Br?ker, Filip Y.F.L. de Vos, Cees J. van Groeningen, Bart C. Kuenen, Helen E. Gall, Michael H READ MORE
http://clincancerres.aacrjournals.org/cgi/content/full/12/6/1760...

Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis

Votes:17 Comments:0
Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis February 2006 Mark S. Rouse, Kerryl E. Piper, Melissa Jacobson, David J. Jacofsky, James M. Steckelberg, and Robin READ MORE
http://jac.oxfordjournals.org/cgi/content/full/57/2/301...

Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 Polymorphisms with the Pharmaco...

Votes:30 Comments:0
Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 Polymorphisms with the Pharmacokinetics of Paclitaxel Nov 2005 Anja Henningsson, Sharon Marsh, Walter J. Loos, Mats O. Karlsson, Adam Garsa, Klaus READ MORE
http://clincancerres.aacrjournals.org/cgi/content/full/11/22/8097...

Paclitaxel Repackaged in an Albumin-Stabilized Nanoparticle: Handy or Just a Dan...

Votes:39 Comments:0
Paclitaxel Repackaged in an Albumin-Stabilized Nanoparticle: Handy or Just a Dandy? Nov 2005 Alex Sparreboom, Sharyn D. Baker, and Jaap Verweij Journal of Clinical Oncology Clinical Pharmacology READ MORE
http://www.jco.org/cgi/content/full/23/31/7765...

FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUE...

Votes:14 Comments:0
FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUENCE OF CELL LINE AND MODULATOR CONCENTRATION ON P-GP ACTIVITY Nov 2005 Mitchell E. Taub, Lalitha Podila, Diane Ely, READ MORE
http://dmd.aspetjournals.org/cgi/content/full/33/11/1679...

Complete Tumor Response Following Intratumoral 32P BioSilicon on Human Hepatocel...

Votes:28 Comments:0
Complete Tumor Response Following Intratumoral 32P BioSilicon on Human Hepatocellular and Pancreatic Carcinoma Xenografts in Nude Mice Oct 2005 Kai Zhang, Susan L.E. Loong, Steve Connor, Sidney W. READ MORE
http://clincancerres.aacrjournals.org/cgi/content/full/11/20/7532...

Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2...

Votes:23 Comments:0
Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y12 Antagonist, With Clopidogrel in Percutaneous Coronary Intervention: Results of the Joint Utilization of Medication READ MORE
http://circ.ahajournals.org/cgi/content/full/111/25/3366...

Antibody Response to Inhaled Insulin in Patients with Type 1 or Type 2 Diabetes....

Votes:36 Comments:0
Antibody Response to Inhaled Insulin in Patients with Type 1 or Type 2 Diabetes. An Analysis of Initial Phase II and III Inhaled Insulin (Exubera) Trials and a Two-Year Extension Trial Jun 2005 S. READ MORE
http://jcem.endojournals.org/cgi/content/full/90/6/3287...

Lower Inhibitor Development in Hemophilia A Mice following Administration of Rec...

Votes:11 Comments:0
Lower Inhibitor Development in Hemophilia A Mice following Administration of Recombinant Factor VIII-O-Phospho-L-serine Complex May 2005 Vivek S. Purohit, Karthik Ramani, Rita Sarkar, Haig H. Kaza READ MORE
http://www.jbc.org/cgi/content/full/280/18/17593...

Acetaminophen and the Risk of Asthma: The Epidemiologic and Pathophysiologic Evi...

Votes:6 Comments:0
Acetaminophen and the Risk of Asthma: The Epidemiologic and Pathophysiologic Evidence Feb 2005 Ihuoma Eneli, Katayoun Sadri, Carlos Camargo, Jr, and R. Graham Barr Chest Abstract The preval READ MORE
http://www.chestjournal.org/cgi/content/full/127/2/604...

REPLICATION OF CHIMERIC YELLOW FEVER VIRUS-DENGUE SEROTYPE 1?4 VIRUS VACCINE STR...

Votes:39 Comments:0
REPLICATION OF CHIMERIC YELLOW FEVER VIRUS-DENGUE SEROTYPE 1?4 VIRUS VACCINE STRAINS IN DENDRITIC AND HEPATIC CELLS Jan 2005 SAMANTHA BRANDLER, NATHAN BROWN, THOMAS H. ERMAK, FRED MITCHELL, MEGAN READ MORE
http://www.ajtmh.org/cgi/content/full/72/1/74...

PHI-443: A Novel Noncontraceptive Broad-Spectrum Anti-Human Immunodeficiency Vir...

Votes:34 Comments:0
PHI-443: A Novel Noncontraceptive Broad-Spectrum Anti-Human Immunodeficiency Virus Microbicide Dec 2004 Osmond J. D'Cruz, Peter Samuel, and Fatih M. Uckun BIOLOGY OF REPRODUCTION ABSTRACT P READ MORE
http://www.biolreprod.org/cgi/content/full/71/6/2037...

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of an Orally Active...

Votes:9 Comments:0
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of an Orally Active Novel Camptothecin Analog, DRF-1042, in Refractory Cancer Patients in a Phase I Dose Escalation Study Jul 2004 Aran READ MORE
http://jcp.sagepub.com/cgi/content/abstract/44/7/723...
Toxicity Limits - Protein Formulation
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