Use of microbiology non-viral substances for treating acne

/Home/Lyophilization and Protein Formulation Patents/Patents - Biologics

Use of microbiology non-viral substances for treating acne
Inventor: ZOUBOULIS CHRISTOS C (DE)
EC: C12N15/11B5; C12N15/11B7
iPC: A61P17/10; C12N15/11; A61K38/00
Publication info: US2005053580
Date: 2005-03-10
Abstract of US2005053580
This is to describe the use of at least one molecular-biologically prepared non-viral active agent (antisense oligonucleotides, ribozymes, stabilized ribozymes, aptamers, mirror aptamers, chimeric RNA/DNA oligonucleotides, naked plasmid-DNA or liposomally encapsulated DNA), especially an antisense oligonucleotide having specificity for a nucleic acid target sequence of the genes, which codes for steroid hormone receptors and/or steroid hormone metabolizing enzymes, especially for the androgen receptor and/or the 5alpha-reductase, for the treatment of acne and acneiform dermatoses including rosacea. For this purpose, preferably specific antisense oligonucleotides and degenerated sequences thereof are selected and preferably introduced by a liposome-mediated transfection into the target cells, especially human sebocytes and/or keratinocytes. In these target cells, a specific inhibition of the androgen-induced, especially of the testosterone-induced stimulation of the sebocyte and/or keratinocyte proliferation by the described antisense oligonucleotides has been determined and evaluated. The effects according to the invention have been detected by way of example with the aid of the sebocyte cell line SZ95 and primary keratinocytes of the skin.