UNIVERSAL TARGET SEQUENCES FOR SIRNA GENE SILENCING
UNIVERSAL TARGET SEQUENCES FOR SIRNA GENE SILENCING
Publication number: CA2562673
Publication date: 2005-11-03
Inventor: HONIGMAN ALIK (IL); LEVAOT NOAM (IL); PANET AMOS (IL)
Applicant: YISSUM RES DEV CO (IL)
Classification:
- international: C12N15/11; A61K31/713; C12N15/11; A61K31/713;
- European:
Application number: CA20052562673 20050421
Priority number(s): US20040564214P 20040422; WO2005IL00437 20050421
Abstract of CA2562673
The present invention provides methods for designing a sequence for efficien t short interference RNA molecules. In particular, the present invention defin es a universal target for siRNA derived from the consensus sequence of the polyadenylation signal in conjunction with unique sequences for gene silenci ng and inhibition of viral replication in a eukaryotic host cell. The present invention further provides methods for the treatment and prevention of diseases and disorders by silencing a gene of a virus, an oncogene, genes encoding transcription factors and many other diseases related genes.</SDOAB >
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