Target validation assay
Target validation assay
Publication number: US2006198789
Publication date: 2006-09-07
Inventor: WENG ZHIGANG (US); GYURIS JENO (US); CLARK STEVEN C (US)
Applicant:
Classification:
- international: A61K49/00; C12N5/08; C12N15/87; C12Q1/68; A61K49/00; C12N5/08; C12N15/87; C12Q1/68;
- european:
Application number: US20060326795 20060106
Priority number(s): US20060326795 20060106; US20050642243P 20050106
Abstract of US2006198789
An method of determining whether a gene of interest is necessary for a tumor cell to maintain its tumorigenicity is disclosed. The method is useful for validation of cancer therapeutic targets in vivo, using shRNAs and tumor xenografts. The inducible shRNA method operates an in vivo RNAi competition assay.
Votes:6
Comments: 0