THREE-DIMENSIONAL SCAFFOLDS FOR TISSUE ENGINEERING MADE BY PROCESSING COMPLEX EXTRACTS OF NATURAL EXTRACELLULAR MATRICES

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THREE-DIMENSIONAL SCAFFOLDS FOR TISSUE ENGINEERING MADE BY PROCESSING COMPLEX EXTRACTS OF NATURAL EXTRACELLULAR MATRICES
Publication Number: WO/2006/138718 International Application No.: PCT/US2006/023813
Publication Date: 28.12.2006 International Filing Date: 19.06.2006

Int. Class.: C12N 5/00 (2006.01), C12N 5/02 (2006.01)
Applicants: DREXEL UNIVERSITY [US/US]; 3141 Chestnut Street, Philadelphia, Pennsylvania 19104 (US) (All Except US).
LELKES, Peter I. [US/US]; 5 Hawthorne Drive, Cherry Hill, New Jersey 08003 (US) (US Only).
LI, Mengyan [CN/US]; 3929 Powelton Avenue, Philadelphia, Pennsylvania 19104 (US) (US Only).
PERETS, Anat [IL/US]; 326 Woodbine Avenue, Narberth, Pennsylvania 19072 (US) (US Only).
POBLETE, Honesto [US/US]; 776 S. 3rd Street, Philadelphia, Pennsylvania 19147 (US) (US Only).
LAZAROVICI, Philip [IL/IL]; Moshe Zvi Segal St. 30/6, Ramot, Jerusalem 97289 (IL) (US Only).
Inventors: LELKES, Peter I. [US/US]; 5 Hawthorne Drive, Cherry Hill, New Jersey 08003 (US).
LI, Mengyan [CN/US]; 3929 Powelton Avenue, Philadelphia, Pennsylvania 19104 (US).
PERETS, Anat [IL/US]; 326 Woodbine Avenue, Narberth, Pennsylvania 19072 (US).
POBLETE, Honesto [US/US]; 776 S. 3rd Street, Philadelphia, Pennsylvania 19147 (US).
LAZAROVICI, Philip [IL/IL]; Moshe Zvi Segal St. 30/6, Ramot, Jerusalem 97289 (IL).
Agent: VOLIN, Marina E.; CAESAR, RIVISE, BERNSTEIN, COHEN & POKOTILOW, LTD., Seven Penn Center, 1635 Market Street, 11th Floor, Philadelphia, Pennsylvania 19103 (US).
Priority Data: 60/691,612 17.06.2005 US

Abstract:
Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.