THERAPEUTIC PLATELETS AND METHODS

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Patent number: WO2005020893
Publication date: 2005-03-10
Inventor: CROWE JOHN H (US); TABLIN FERN (US); WOLKERS WILLEM F (NL); WALKER NAOMI J (US); AUH JOONG-HYUCK; TANG MINKE; LOOPER SHERI
Applicant: UNIV CALIFORNIA (US);; CROWE JOHN H (US);; TABLIN FERN (US);; WOLKERS WILLEM F (NL);; WALKER NAOMI J (US);; AUH JOONG-HYUCK;; TANG MINKE;; LOOPER SHERI
Classification:
- international: A61K
- european:
Application number: WO2004US25653 20040806
Priority number(s): US20030635333 20031006; US20030722200 20031125
Abstract of WO2005020893
The invention provides methods for loading a preservative into blood platelets comprising providing a preservative solution having a preservative, water and protein, and loading blood platelets with the preservative solution to produce preservative-loaded blood platelets having the preservative solution generally including higher glass transition temperatures than glass transition temperatures for a preservative solution having the preservative, water and no protein. A process for processing blood platelets comprising suspending blood platelets in a preservative solution at a concentration greater than about 108 platelets per ml. of preservative solution to produce preservative-loaded blood platelets, freeze-drying the preservative-loaded blood platelets, and recovering at least 75% of the freeze-dried platelets. A platelet composition comprising blood platelets loaded with a preservative solution having a preservative, water, and protein, and generally further having higher glass transition temperatures than glass transition temperatures for blood platelets loaded with the preservative, water, but no protein.