Synthetic method for thiagabine and its raceme and S-configuration and its method for preparing amorphous powder

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Patent number: CN1554654
Publication date: 2004-12-15
Inventor: JIANG CHANGSHENG (CN); ZHANG JIANGE (CN); XU LINFENG (CN)
Applicant: SHANGHAI INST ORGANIC CHEM (CN)
Classification:
- international: C07D333/06; C07D333/16; C07D409/06; A61P25/08
- european:
Application number: CN200310122778 20031224
Priority number(s): CN200310122778 20031224
Abstract of CN1554654

The present invention provides the synthesis process of thiagabine and its raceme and S-configuration as well as its new precursor and its preparation process. The prepared racematic or optically active thiagabine crystal may be dissolved in water and freeze dried to obtain amorphous powder. The synthesis path of the present invention has no need of expensive special reagent and is mild in reaction condition and suitable for industrial production.
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