Substituted inositols and their use

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United States Patent Application 20050143290
Kind Code A1
Rademacher, Thomas William ; et al. June 30, 2005
Substituted inositols and their use
Abstract
Inositol phosphate esters and conjugates formed between the compounds and a coupling partner are disclosed, in particular compounds based on a myo-inositol which is substituted at position 1 with a phosphate ester group, at position 2 with a sugar group and at position 4 and/or position 6 with an amino acid group. The compounds are based on the structure of phosphatidylinositol hexamannosides (PIM6) of Mycobacteria and may be used as mimics of the naturally occurring PIMs in order to induce biological responses normally attributed to the natural compound or may be used as biologically inert carriers in order to deliver specific pharmaceutically active compounds to lipid rafts/caveolae.
Inventors: Rademacher, Thomas William; (Oxford, GB) ; Schmidt, Richard; (Konstanz, DE) ; Stadelmaier, Andreas; (Mutlangen, DE)
Correspondence Name and Address: DANN, DORFMAN, HERRELL & SKILLMAN
1601 MARKET STREET
SUITE 2400
PHILADELPHIA
PA
19103-2307
US
Serial No.: 504605
Series Code: 10
Filed: February 18, 2005
PCT Filed: February 13, 2003
PCT NO: PCT/GB03/00604
U.S. Current Class: 514/7; 514/25; 530/332; 536/108
U.S. Class at Publication: 514/007; 514/025; 530/332; 536/108
Intern'l Class: A61K 038/16; C08B 033/02