Stabilization control of small heat shock proteins in cellular chaperone protection systems

Stabilization control of small heat shock proteins in cellular chaperone protection systems
Engineering Village 2
? 2006 Elsevier Inc
Accession number: 8928129

Title: Stabilization control of small heat shock proteins in cellular chaperone protection systems

Authors: Hong-Chu Chen1 ; Hsiao-Ching Lee; Tsai-Yun Lin; Bor-Sen Chen

Author affiliation: 1 Lab. of Syst. Biol., Nat. Tsing Hua Univ., Hsinchu, Taiwan

Serial title: Journal of the Chinese Institute of Engineers

Abbreviated serial title: J. Chin. Inst. Eng. (Taiwan)

Volume: 29

Issue: 2

Publication date: March 2006

Pages: 361-73

Language: English

ISSN: 0253-3839


Document type: Journal article (JA)

Publisher: Chinese Inst. Eng

Country of publication: Taiwan

Material Identity Number: J305-2006-004

Abstract: The role of small heat shock proteins (sHsps) in the cellular chaperone system was examined with application of the feedback control technique widely used in engineering for stabilizing a specific system. We proposed a dynamic feedback control model for the thermotolerance machinery of sHsps from the system biology perspective, and for the first time verified that a system stabilization feedback control scheme is involved in the chaperone protecting activity under heat shock conditions. In the dynamic model, of the chaperone protection system, the defense mechanism of sHsps is a sigmoid function and the influence of environment temperatures is a bell-shaped function. The close fit of the system dynamic behaviors to the kinetic data suggests that our system stabilization control model matches the protective mechanism conveyed by sHsps. Furthermore, the temporal changes of the unfolded intermediates and the sHsp-substrate complexes can be predicted by the proposed dynamic stabilization model, which are not easily measured in biochemical experiments. The identified feedback control matrix can be viewed as a biochemical interaction for measuring the protective activity of sHsps qualitatively and quantitatively. Our work introduces an innovative approach for analysis and detecting the kinetics of sHsps to resist protein aggregation from the system stabilization point of view

Number of references: 30

Inspec controlled terms: biochemistry - biotechnology - chemical variables control - feedback - feedforward - proteins - stability

Uncontrolled terms: stabilization control - small heat shock proteins - cellular chaperone protection systems - dynamic feedback control model - thermotolerance machinery - system biology - dynamic model - sigmoid function - bell-shaped function - dynamic stabilization model - biochemical interaction - protein aggregation - system stabilization

Inspec classification codes: C3350G Control applications in chemical and oil refining industries - C3120P Chemical variables control - C1320 Stability in control theory - C1310 Control system analysis and synthesis methods

Treatment: Theoretical or Mathematical (THR); Experimental (EXP)

Discipline: Computers/Control engineering (C)

Database: Inspec

Copyright 2006, The Institution of Engineering and Technology
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