STABILIZERS FOR LYOPHILIZED VACCINES - Patent Pending

12) Patent Application: (11) CA 2333505
ABSTRACT:
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7?
72) Inventors (Country): SHEU, SU-PI (United States)
VOLKIN, DAVID B. (United States)
BURKE, CARL J. (United States)
(73) Owners (Country): MERCK & CO., INC. (United States)
(71) Applicants (Country): MERCK & CO., INC. (United States)
(74) Agent: GOWLING LAFLEUR HENDERSON LLP
(45) Issued:
(86) PCT Filing Date: May 28, 1999
(87) PCT Publication Date: Dec. 9 , 1999
(51) International Class (IPC): C12N 7/00
C07H 3/04
A61K 31/045
A61K 39/12
A61K 9/19
Patent Cooperation Treaty (PCT): Yes (85) National Entry: Nov. 28, 2000
(86) PCT Filing number: PCT/US1999/012026
(87) International publication number: WO1999/062500
(30) Application priority data: Application No. Country Date
09/089,743 United States June 3 , 1998
Availability of licence: N/A
Language of filing: English