Regulation of translation for recombinant protein production
Regulation of translation for recombinant protein production
United States Patent 7,091,004
Morris , et al.
August 15, 2006
Inventors: Morris; Arvia E. (Seattle, WA), Wong-Madden; Sharon T. (Bellevue, WA)
Assignee: Immunex Corporation (Seattle, WA)
Appl. No.: 10/165,591
Filed: June 7, 2002
Abstract
The invention provides cells that produce increased levels of recombinant protein by modulating the activity of translational regulator gene products that are downstream targets of PKB alpha, methods of making such cells, and methods of using such cells. Such translational regulator gene products include 4E-BP1 and mTOR.
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