Rapid acting freeze dried oral pharmaceutical composition for treating migraine - Patent Pending

Patent number: US2005084530
Publication date: 2005-04-21
Inventor: RAO PAVULURI V (IN); KHADGAPATHI PODILI (IN)
Applicant: NATCO PHARMA LTD (IN)
Classification:
- international: A61K31/48; A61K31/405; A61K9/20
- european: A61K9/00M18B; A61K9/20P; A61K31/138; A61K31/4045; A61K31/4196; A61K31/42; A61K31/48
Application number: US20040984227 20041029
Priority number(s): WO2000IN00078 20000825; IN1999MA01160 19991201; US20020148647 20020530; US20040984227 20041029
Abstract of US2005084530
The present invention relates to a novel freeze-dried pharmaceutical composition useful for the treatment of migraine and associated symptoms at a reduced total dose of active substance than required for oral administration in the form of a tablet containing a porous matrix net work of a water soluble or water dispersible carrier material, a pharmaceutically active substance(s); organoleptic additives such as sweetening agents, flavouring agents, coloring agents; pharmaceutically acceptable preservatives; solublising agents; surfaceactive agents and/or buffering agents. The pharmaceutical composition optionally may contain other additives such as permeation enhancers, chelating salts and stabilising agents. The present invention also relates to a process for preparation of the above said composition and its use.
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