RNAi probes targeting cancer-related proteins - European Patents

RNAi probes targeting cancer-related proteins
Publication number: US2006178329
Publication date: 2006-08-10
Inventor: GLEAVE MARTIN (CA); JANSEN BURKHARD (CA); TROUGAKOS IOANNIS P (GR); GONOS EFSTATHIOS (GR); SIGNAEVSKY MAXIM (CA); BERALDI ELIANA (CA)
Applicant: UNIV BRITISH COLUMBIA (CA)
Classification:
- international: A61K48/00; A61K31/712; C07H21/02; C12N15/11; A61K38/00; A61K48/00; A61K31/712; C07H21/00; C12N15/11; A61K38/00
- european: A61K31/712; C12N15/11B
Application number: US20060276300 20060223
Priority number(s): US20060276300 20060223; US20030646436 20030821; US20020405193P 20020821; US20020408152P 20020903; US20030472387P 20030520
Abstract of US2006178329

RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention farther provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment