RNA recognition and recognition control of -peptide ribonucleic acids containing arginine residue by external factors - RNA

RNA recognition and recognition control of -peptide ribonucleic acids containing arginine residue by external factors
2006
Takehiko Wada1,2, Yoshiki Maeda1, Nobuya Sawa1, Hirofumi Sato2, Shiroh Futaki3 and Yoshihisa Inoue1,4
1 Department of Applid Chemistry, Graduate School of Engineering, Osaka University, Yamada-oka, Suita 565-0871, Japan, 2 PRESTO, JST, Yamada-oka, Suita 565-0871, Japan, 3 Institute for Chemical reseach, Kyoto University, Uji, Kyoto 611-0011, Japan, 4 ICORP Entropy Control Project, JST, 4-6-3 Kamishinden, Toyonaka 565-0085, Japan
Nucleic Acids Symposium Series 2006
A novel nucleic acid model using -peptide ribonucleic acid (-PRNA) possessing alternative -PRNA/lysine and -PRNA/arginine sequences, where the lysine or arginine residue are expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between basic amino acid side-chain groups and DNA's phosphate anions on the backbone. These -PRNAs form stable sequence-specific complex with the complementary DNA.
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