Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
United States Patent Application 20050107365
Kind Code A1
Becker, Cyrus Kephra ; et al. May 19, 2005
Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
Abstract
This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: 1 wherein Z is --C(O)-- or --S(O).sub.2--, X is carbon or nitrogen, Y is carbon, and X-Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatic ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring, chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
Inventors: Becker, Cyrus Kephra; (Menlo Park, CA) ; Caroon, Joan Marie; (Moutain View, CA) ; Melville, Chris Richard; (Palo Alto, CA) ; Padilla, Fernando; (Fremont, CA) ; Pfister, Jurg Roland; (Los Altos, CA) ; Zhang, Xiaoming; (Campbell, CA)
Correspondence Name and Address: ROCHE PALO ALTO LLC
PATENT LAW DEPT. M/S A2-250
3431 HILLVIEW AVENUE
PALO ALTO
CA
94304
US
Serial No.: 971522
Series Code: 10
Filed: October 22, 2004
U.S. Current Class: 514/223.2; 514/259.1; 514/266.21; 544/13; 544/281; 544/284
U.S. Class at Publication: 514/223.2; 514/259.1; 514/266.21; 544/013; 544/284; 544/281
Intern'l Class: A61K 031/549; A61K 031/519; A61K 031/517; C07D 487/04
Comments: 0
Votes:10