Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery - Protein

Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery
11 May 2006
Sunday A. Shoyele, and Alex Slowey
International Journal of Pharmaceutics
Abstract
Formulation of proteins/peptides for therapeutic uses has often posed some challenges to drug formulators. The main problem is the relatively weak forces involved in the native conformation of these proteins and so making them quite labile. Furthermore, their susceptibility to proteolytic enzymes in the gut makes oral administration quite challenging. While various routes like, ocular, transdermal, nasal and buccal have been tried, none of these routes has proved to be a potential alternative to the invasive injection. However, various studies have been performed on the formulation of these proteins as aerosols for pulmonary delivery and promising results have been obtained. This article looks at the prospects of inhaled proteins as a delivery route for systemic activity.
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