Preparation of submicron sized nanoparticles via dispersion lyophilization

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Patent Number: US2005013868
Publication date: 2005-01-20
Inventor(s): BRYNJELSEN SEAN [US]; DOTY MARK [US]; KIPP JAMES E [US]; JAYSWAL NAILESH [US]; NARAYANAN KRISHNASWAMY [US]
Applicant(s):
Requested Patent: US2005013868
Application Number: US20040920578 20040817
Priority Number(s): US20020183035 20020626; US20040920578 20040817; US20020964273 20020510
IPC Classification: A61K9/14
EC Classification: A61K9/14H4, A61K9/51, B01J13/04
Equivalents:
Abstract
The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
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