Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents
United States Patent Application 20050154004
Kind Code A1
Banwell, Martin Gerhardt ; et al. July 14, 2005
Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents
Abstract
A method for the preparation of a compound of general Formula: 1 or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general Formula: 2 wherein, A is a cyclic or non-cyclic group; Z is a carbon or a heteroatom; n is selected from 0, 1, 2 or 3; W, X and Y may be the same or different and each are selected from hydrogen; optionally substituted alkyl, alkenyl, alkynyl, amino, alkoxy, alkenoxy, alkynoxy, aryl, alkylthio, heterocyclyl; carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, halogen, nitro, sulfate, phosphate, cyano and optionally protected hydroxy; or W and X, together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group is provided.
Inventors: Banwell, Martin Gerhardt; (Aranda, AU) ; Flynn, Bernard Luke; (Griffith, AU)
Correspondence Name and Address: GREENLEE WINNER AND SULLIVAN P C
4875 PEARL EAST CIRCLE
SUITE 200
BOULDER
CO
80301
US
Serial No.: 073974
Series Code: 11
Filed: March 7, 2005
U.S. Current Class: 514/283; 546/51
U.S. Class at Publication: 514/283; 546/051
Intern'l Class: A61K 031/4745; C07D 471/14
Comments: 0
Votes:22