Preparation and physical characterization of a novel marine oil emulsion as a potential new formulation vehicle for lipid soluble drugs - Surfactants

Preparation and physical characterization of a novel marine oil emulsion as a potential new formulation vehicle for lipid soluble drugs
Received 6 March 2006; revised 15 June 2006; accepted 19 June 2006. Available online 29 June 2006.
Guohui Cuia, 1, Lili Wanga, Philip J. Davisb, Mohameditaki Karaa and Hu Liua, b, ,
International Journal of Pharmaceutics
Volume 325, Issues 1-2 , 15 November 2006
ScienceDirect
Copyright ? 2006 Elsevier B.V. All rights reserved.
aSchool of Pharmacy, Memorial University of Newfoundland, St. John's, Nfld, Canada A1B 3V6
bDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, Nfld, Canada
Abstract
Emulsions often contain vegetable oils such as soybean oil. In this study, a 10% (w/w) of marine mammal oil emulsion was prepared. The effect of a group of emulsifying agents on the stability of the 10% of seal oil emulsion was examined. The emulsifying agents studied were hydrogenated castor oil coated with various polyoxyethylene derivatives. It was found that 2.5% of HCO-40 resulted in the most stable seal oil emulsion. The size of the emulsified droplets defined by their diameters was found to be around 240?270 nm. The initial zeta-potential and pH value of the emulsion were found to be around -27 mV and 3.5, respectively, which decreased over time, to about -31 mV and 2.4, respectively. This is believed to be a result of the hydrolysis of triacylglycerides into free fatty acids in the emulsion. The effect of various amounts of Crodasinic LS-30, a negatively charged surfactant, and Incroqal Behenyl TMS, a positively charged surfactant, on the emulsion was investigated. It was shown that Crodasinic LS-30 had very little effect on the particle size, zeta-potential and pH, while the effect of Incroquat Benhenyl TMS was found to be dependent upon the concentration of the surfactant used.
Keywords: Seal oil emulsion; Zeta-potential; Particle size; Emulsifying agents; Hydrogenated castor oil; Crodasinic LS-30; Incroqal Behenyl TMS

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1 Current address: School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, China.
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