Poxvirus containing formulations and process for preparing stable poxvirus containing compositions

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Patent Number: US2005019349
Publication date: 2005-01-27
Inventor(s): HOWLEY PAUL [AU]; HELLER KARL [DE]; RATHE INGMAR [DE]
Applicant(s):
Requested Patent: US2005019349
Application Number: US20040496858 20040526
Priority Number(s): DK20010001831 20011210; WO2002EP13434 20021128
IPC Classification: A61K39/275; A61K39/285; A61K9/14
EC Classification: A61K9/19, A61K39/275
Equivalents: AU2002361962, BR0214822, CA2467365, EP1418942 (WO03053463), A3, HU0402179, JP2005513109T, WO03053463
Abstract
The present invention relates to a formulation, in particular an aqueous formulation comprising (i) a poxvirus of one of the genera orthopoxvirus, avipoxvirus, parapoxvirus, capripoxvirus and suipoxvirus, (ii) a disaccharide, (iii) a pharmaceutically acceptable polymer and optionally (iv) a buffer. The aqueous formulation is particularly suitable for freeze drying processes resulting in a stable, freeze-dried, poxvirus containing composition. The invention further concerns a method for preparing a freeze-dried, pox virus containing composition and the thus obtained product.

Data supplied from the esp@cenet database - l2