Powder compositions - Patent Pending

United States Patent Application 20020120228
Kind Code A1
Maa, Yuh-Fun ; et al. August 29, 2002
Powder compositions
Abstract
A gel-forming free-flowing powder suitable for use as a vaccine is prepared by spray-drying or spray freeze-drying an aqueous suspension that contains an antigen adsorbed to an aluminum salt or calcium salt adjuvant, a saccharide, an amino acid or a salt thereof, and a colloidal substance. Powder for vaccine purposes are also prepared by spray freeze-drying an aqueous suspension of such an adjuvant having an antigen adsorbed therein. Processes for forming these powder compositions are also described, as well as methods of using the compositions in a vaccination procedure.
Inventors: Maa, Yuh-Fun; (Fremont, CA) ; Zhao, Lu; (Fremont, CA) ; Prestrelski, Steven J.; (Fremont, CA)
Correspondence Name and Address: Thomas P. McCracken
POWDERJECT TECHNOLOGIES INC.
6511 Dumbarton Circle
Fremont
CA
94555
US
Serial No.: 877726
Series Code: 09
Filed: June 8, 2001
U.S. Current Class: 604/57; 424/204.1; 424/234.1; 514/23; 514/53; 604/68
U.S. Class at Publication: 604/57; 604/68; 424/204.1; 424/234.1; 514/53; 514/23
Intern'l Class: A61K 039/12; A61K 039/02; A61K 031/70