Polyampholytes for delivering polyions to a cell

Polyampholytes for delivering polyions to a cell
United States Patent 7,098,030
Rozema , et al.
August 29, 2006
Inventors: Rozema; David B. (Madison, WI), Budker; Vladimir G. (Middleton, WI), Hagstrom; James E. (Middleton, WI), Trubetskoy; Vladimir (Middleton, WI), Wolff; Jon A. (Madison, WI), Monahan; Sean D. (Madison, WI), Slattum; Paul M. (Madison, WI)
Assignee: Mirus Bio Corporation (Madison, WI)
Appl. No.: 10/899,509
Filed: July 26, 2004
Abstract
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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