Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them
Patent Number: EP0317281, A3, B1
Publication date: 1989-05-24
Inventor(s): POOLE STEPHEN WILLIAM; STANLEY TIMOTHY PAUL; DIVALL GEOFFREY; PACKHAM TERENCE WILLIAM; KNIGHT JOSEPH
Applicant(s): WELLCOME FOUND (GB)
Requested Patent: CA1341114
Application Number: EP19880310805 19881116
Priority Number(s): GB19870027157 19871119
IPC Classification: A61K9/08; A61K9/14; A61K31/195; C07C101/447
EC Classification: A61K31/195, A61K47/10, A61K47/12, A61K47/32
Equivalents: AU2574888, AU619781, DE3877151D, DE3877151T, DK172794B, DK646688, ES2052745T, FI885358, FI90204B, FI90204C, GR3007287T, HK108994, HU203197, HU48198, IE63996, IL88419, JP1153628, JP2693191B2, KR9702607, NZ227004, PT89028, US4997651, ZA8808674
Cited Documents: FR2285855; EP0212853; DE1292660; EP0233733; GB750155; RO57195; RO57195
Abstract
The present invention relates to a new two-component pharmaceutical formulation of melphalan in which the two components comprise a) freeze-dried mephalan hydrochloride and b) a solvent-diluent comprising a citrate, propylene glycol and ethanol. Substantially pure melphalan, substantially pure melphalan hydrochloride and methods for preparing them are also described.
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