Pharmaceutical composition with RNA as cofactor of hemostasis

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Pharmaceutical composition with RNA as cofactor of hemostasis
Inventor: PREISSNER KLAUS (DE); NAKAZAWA FUMIE (JP)
Applicant: AVENTIS BEHRING GMBH (DE)
EC: A61K31/7088; A61K31/7105
IPC: G01N33/50; A61K31/7088; A61K31/7105
Publication info: EP1391205
Date: 2004-02-25
Abstract of EP1391205
A composition for promoting coagulation of blood comprising a natural or synthetic RNA, or its fragments or analogs, e.g. peptide nucleic acids, ribozymes or RNA aptamers (collectively (A)), is new. Independent claims are also included for: (1) composition for promoting fibrinolysis or for inhibiting coagulation containing one or more agents (B) that degrade RNA or inhibitory compounds with RNase activity or RNA-complexing capacity; (2) diagnostic process for detecting post-operative hypercoagulative states, complication of pregnancy, tumor status, acute myocardial infarction or sepsis by detecting increased levels of plasma RNA, relative to healthy subjects; and (3) diagnostic agent, containing (A), for qualitative or quantitative determination of the blood coagulation factor VII-activating protein (FSAP) or its proenzyme.