Peptide II

/Home/Lyophilization and Protein Formulation Patents/Patent Articles - Lyophilization/Patent Pending - Lyophilization

United States Patent Application 20050118597
Kind Code A1
Carroll, Miles ; et al. June 2, 2005
Peptide II
Abstract
There is provided an MHC class II peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the minimal epitope from the amino acid sequence shown as SEQ ID No. 2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 3; (iii) a minimal epitope from the region 281-420 of 5T4. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.
Inventors: Carroll, Miles; (Oxford, GB) ; Harrop, Richard; (Oxford, GB) ; Kingsman, Susan; (Oxford, GB)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Serial No.: 504603
Series Code: 10
Filed: August 12, 2004
PCT Filed: February 13, 2003
PCT NO: PCT/GB03/00618
U.S. Current Class: 435/6; 424/144.1; 435/320.1; 435/372; 435/69.1; 435/7.23; 530/350; 530/388.22; 536/23.5
U.S. Class at Publication: 435/006; 435/007.23; 435/069.1; 435/320.1; 435/372; 530/350; 530/388.22; 424/144.1; 536/023.5
Intern'l Class: C12Q 001/68; G01N 033/574; C07H 021/04; A61K 039/395; C07K 014/74; C07K 016/30