Pearl oyster monomer polysaccharide ZBP-I and extraction method and uses in preparation of drugs for tumor

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Pearl oyster monomer polysaccharide ZBP-I and extraction method and uses in preparation of drugs for tumor
Inventor: WU HAO (CN); CHEN WENXING (CN)
Applicant: NANJING UNIVERSITY OF TRADITIO (CN)
IPC: A61K31/715; A61P35/00; C08B37/02
Publication info: CN1544478
Date: 2004-11-10
Abstract of CN1544478
The invention discloses a process for separating and purifying pearl oyster monomer polysaccharide ZBP-I from the crude polysaccharides extracted from pearl oyster, which comprises, dissolving the crude polysaccharide powder into water, charging into cellulose columns, eluting with dissolvent, subjecting the eluent to hyperfiltration by ultrafilter membrane and vacuum drying or lyophilization to prepare pearl oyster polysaccharide I powder, dissolving the polysaccharide I in water, separating through Sephadex G-200 column, the pearl oyster monomer polysaccharide ZBP-I is finally obtained from the eluent through alcohol deposition of polysaccharide, filtering, vacuum drying or freeze drying. The monomer polysaccharide ZBP-I exhibites appreciable enhancing action for the anti-tumor activity of the natural killer NK cells.