Particle engineering techniques for inhaled biopharmaceuticals - Spray Drying

Particle engineering techniques for inhaled biopharmaceuticals
Received 14 March 2006; accepted 25 July 2006. Available online 12 August 2006.
Sunday A. Shoyele, a, and Simon Cawthornea
Advanced Drug Delivery Reviews
Volume 58, Issues 9-10 , 31 October 2006
ScienceDirect
Copyright ? 2006 Elsevier B.V. All rights reserved.
Abstract
Formulation of biopharmaceuticals for pulmonary delivery is faced with the challenge of producing particles with the optimal properties for deep lung deposition without altering the native conformation of these molecules. Traditional techniques such as milling are continuously being improved while newer and more advanced techniques such as spray drying, spray freeze drying and supercritical fluid technology are being developed so as to optimize pulmonary delivery of biopharmaceuticals. While some of these techniques are quite promising, some are harsh and impracticable. Method scale up, cost-effectiveness and safety issues are important factors to be considered in the choice of a technique. This paper reviews the presently developed techniques for particle engineering biopharmaceuticals.
Keywords: Biopharmaceuticals; Protein/peptide; Particle engineering; Aerodynamic diameter; Spray drying; Supercritical fluid

This review is part of the Advanced Drug Delivery Reviews theme issue on Challenges & Innovations in Effective Pulmonary Systemic & Macromolecular Drug Delivery", Vol. 58/9?10, 2006.
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