PROCESS FOR AMORPHOUS ESOMEPRAZOLE

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PROCESS FOR AMORPHOUS ESOMEPRAZOLE
Publication Number: WO/2007/054951 International Application No.: PCT/IN2005/000367
Publication Date: 18.05.2007 International Filing Date: 14.11.2005

Int. Class.: C07D 401/12 (2006.01)
Applicants: HETERO DRUGS LIMITED [IN/IN]; Hetero House, 8-3-166/7/1, Erragadda, Hyderabad, Andhrapradesh, Hyderabad 500018 (IN) (All Except US).
PARTHASARADHI REDDY, Bandi [IN/IN]; Hetero House, 8-3-166/7/1, Erragadda, Hyderabad, Andhrapradesh, Hyderabad 500018 (IN) (US Only).
RATHNAKAR REDDY, Kura [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN) (US Only).
RAJI REDDY, Rapolu [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN) (US Only).
MURALIDHARA REDDY, Dasari [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN) (US Only).
Inventors: PARTHASARADHI REDDY, Bandi [IN/IN]; Hetero House, 8-3-166/7/1, Erragadda, Hyderabad, Andhrapradesh, Hyderabad 500018 (IN).
RATHNAKAR REDDY, Kura [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN).
RAJI REDDY, Rapolu [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN).
MURALIDHARA REDDY, Dasari [IN/IN]; Hetero Drugs Limited (R & D), Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad 500018 (IN).
Title: PROCESS FOR AMORPHOUS ESOMEPRAZOLE

Abstract: The present invention relates to a commercially viable process for preparation of amorphous esomeprazole. Thus, amorphous esomeprazole is prepared by suspending esomeprazole in water and then subjecting the suspension to lyophilization at -70?C.