PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES - European Patents

PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES
Engineering Village
Publication number: EP1169460

Patent number: 1169460

Patent authority: EP

Kind: B1 - Patent

Title: PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES

Inventors: LIU, Bianling (IL) ; RUBINSTEIN, Menachem (IL) ; NOVICK, Daniela (IL) ; GRABER, Pierre (CH)

Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Attorney, Agent or Firm: Weiss, Wolfgang et al & Weickmann & Weickmann Patentanw?lte Postfach 86 08 20

Publication date: 05/17/2006

Publication year: 2006

Application number: 00919108.1

Filing date: 04/13/2000

Document type: European Grant

Priority information: IL 12942799 04/13/1999

IPC-8 Code: C12N 15/57 SECTION C CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, enzymes, fermentates, or substances produced by, or extracted from, micro-organisms or animal material ; food compositions , ; medicinal preparations ; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles ; fertilisers ; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS preservation of living parts of humans or animals ; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA microbiological testing media 3
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor mutants or genetically engineered micro-organisms , , ; new plants ; plant reproduction by tissue culture techniques ; new animals ; use of medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases, gene therapy ; peptides in general 3,5,6
Recombinant DNA-technology 5
acting on peptide bonds (3.4) 5

C12N 15/24 SECTION C CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, enzymes, fermentates, or substances produced by, or extracted from, micro-organisms or animal material ; food compositions , ; medicinal preparations ; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles ; fertilisers ; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS preservation of living parts of humans or animals ; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA microbiological testing media 3
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor mutants or genetically engineered micro-organisms , , ; new plants ; plant reproduction by tissue culture techniques ; new animals ; use of medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases, gene therapy ; peptides in general 3,5,6
Recombinant DNA-technology 5
Interleukins 5

C12N 15/62 SECTION C CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, enzymes, fermentates, or substances produced by, or extracted from, micro-organisms or animal material ; food compositions , ; medicinal preparations ; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles ; fertilisers ; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS preservation of living parts of humans or animals ; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA microbiological testing media 3
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor mutants or genetically engineered micro-organisms , , ; new plants ; plant reproduction by tissue culture techniques ; new animals ; use of medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases, gene therapy ; peptides in general 3,5,6
Recombinant DNA-technology 5
DNA sequences coding for fusion proteins 5

C12N 9/64 SECTION C CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, enzymes, fermentates, or substances produced by, or extracted from, micro-organisms or animal material ; food compositions , ; medicinal preparations ; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles ; fertilisers ; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS preservation of living parts of humans or animals ; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA microbiological testing media 3
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof preparations containing enzymes for cleaning teeth ; medicinal preparations containing enzymes or proenzymes ; enzyme containing detergent compositions ; Processes for preparing, activating, inhibiting, separating, or purifying enzymes preparation of malt 3
Hydrolases (3.) 3
derived from animal tissue, e.g. rennin 3
ECLA Code: C07K14/54 CHEMISTRY; METALLURGY
ORGANIC CHEMISTRY such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01 ; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44 ; macromolecular compounds C08 ; dyes C09 ; fermentation products C12 ; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P ; production of organic compounds by electrolysis or electrophoresis C25B3/00 , C25B7/00
PEPTIDES peptides in foodstuffs A23 ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J ; preparations for medicinal purposes A61K ; peptides containing beta-lactam rings C07D ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D ; ergot alkaloids of the cyclic peptide type C07D519/02 ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00 ; macromolecular products derived from proteins C08H1/00 ; preparation of glue or gelatine C09H ; single cell proteins, enzymes C12N ; genetic engineering processes for obtaining peptides C12N15/00 ; compositions for measuring or testing processes involving enzymes C12Q ; investigation or analysis of biological material G01N33/00
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
from animals; from humans
Cytokines; Lymphokines; Interferons
Interleukins (IL)

C07K14/545 CHEMISTRY; METALLURGY
ORGANIC CHEMISTRY such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01 ; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44 ; macromolecular compounds C08 ; dyes C09 ; fermentation products C12 ; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P ; production of organic compounds by electrolysis or electrophoresis C25B3/00 , C25B7/00
PEPTIDES peptides in foodstuffs A23 ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J ; preparations for medicinal purposes A61K ; peptides containing beta-lactam rings C07D ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D ; ergot alkaloids of the cyclic peptide type C07D519/02 ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00 ; macromolecular products derived from proteins C08H1/00 ; preparation of glue or gelatine C09H ; single cell proteins, enzymes C12N ; genetic engineering processes for obtaining peptides C12N15/00 ; compositions for measuring or testing processes involving enzymes C12Q ; investigation or analysis of biological material G01N33/00
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
from animals; from humans
Cytokines; Lymphokines; Interferons
Interleukins (IL)
IL-1

C12N9/64F2C22B CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF biocides, pest repellants or attractants, or plant growth regulator