PHARMACEUTICAL COMPOSITION CONTAINING SC(FV)2

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PHARMACEUTICAL COMPOSITION CONTAINING SC(FV)2
Publication Number: WO/2006/132352 International Application No.: PCT/JP2006/311600
Publication Date: 14.12.2006 International Filing Date: 09.06.2006

Int. Class.: A61K 39/395 (2006.01), A61K 47/02 (2006.01), A61K 47/10 (2006.01), A61K 47/18 (2006.01), A61K 47/22 (2006.01), A61K 47/26 (2006.01), A61K 47/46 (2006.01), A61K 9/19 (2006.01), A61P 43/00 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo, 1158543 (JP) (All Except US).
IGAWA, Tomoyuki [JP/JP]; c/o CHUGAI SEIYAKU KABUSHIKI KAISHA, 135, Komakado 1-chome, Gotenba-shi, Shizuoka, 4128513 (JP) (US Only).
Inventor: IGAWA, Tomoyuki [JP/JP]; c/o CHUGAI SEIYAKU KABUSHIKI KAISHA, 135, Komakado 1-chome, Gotenba-shi, Shizuoka, 4128513 (JP).
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP).
Priority Data: 2005-171375 10.06.2005 JP
PCT/JP2006/306800 31.03.2006 JP

Abstract: The inventors found a stabilizing agent/stabilizing condition for suppressing an isomerization reaction of sc(Fv)2. Further, they found that the isomerization reaction thereof can be suppressed by preparing a formulation by lyophilization. That is, they revealed that by applying the found stabilizing agent/stabilizing condition and preparation of a formulation by lyophilization, the isomerization reaction of a sc(Fv)2 molecule from a bivalent scFv to a single chain diabody, and/or the isomerization reaction of a sc(Fv)2 molecule from a single chain diabody to a bivalent scFv can be suppressed in both directions or one direction.