Oral delivery system comprising a drug/polymer complex - Patent Pending

Oral delivery system comprising a drug/polymer complex
Engineering Village
Publication number: US20050287212

Application number: 148673

Unstandardized application number: 11148673

Patent authority: US

Kind: A1 - Utility Patent Application

Title: Oral delivery system comprising a drug/polymer complex

Inventors: Han, Jasmine E. (US) ; Pollock-Dove, Crystal (US) ; Dong, Liang-Chang (US) ; Wong, Patrick S.L. (US)

Publication date: 12/29/2005

Publication year: 2005

Filing date: 06/08/2005

Abstract: This invention pertains to the enhanced delivery of orally administered pharmaceutical agents and methods, dosage forms and devices thereof. In particular, the invention is directed to methods including providing a low solubility drug having a pKa between about 6 and about 9; dissolving the low solubility drug in an aqueous solution, wherein a pH of the aqueous solution is less than about 6.0; dissolving a hydrophilic polymer in the aqueous solution, wherein the weight ratio of the hydrophilic polymer tothe low solubility drug is less than or equal to about 0.15; lyophilizing the aqueous solution to obtain a lyophilized powder. Also disclosed are drug formulations made according to the method, and dosage forms that include the drug formulations.

Document type: US Application

IPC Code: A61K9/48 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations characterised by special physical form nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances
Preparations in capsules, e.g. of gelatin, of chocolate 2

A61K9/24 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations characterised by special physical form nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances
Pills, lozenges or tablets 2
Layered or laminated unitary dosage forms 2

US Classification: 424/473 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
PREPARATIONS CHARACTERIZED BY SPECIAL PHYSICAL FORM
Tablets, lozenges, or pills
Sustained or differential release type
Layered unitary dosage forms
With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)

Database: US Patents

Compilation and indexing terms, ? 2006 LexisNexis Univentio B.V.
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